Therapy Approaches

Mindfulness-Based Cognitive Therapy (MBCT): How It Works, Effectiveness & What to Expect

MBCT is an eight-week group program that combines mindfulness practice with ideas from cognitive therapy to help people with recurrent depression stay well.

On this page
  1. 1. Overview
  2. 2. Historical Origins
  3. 3. Theoretical Foundations
  4. 4. How a Typical Course Works
  5. 5. Core Techniques
  6. 6. Conditions It Treats and Evidence Base
  7. 7. Comparison with Other Therapies
  8. 8. Who Provides It and How to Find a Therapist
  9. 9. Limitations and Criticisms
  10. 10. What to Expect in Your First Sessions
  11. Conclusion
  12. Frequently asked questions
  13. Sources

Mindfulness-Based Cognitive Therapy (MBCT) is an eight-week, group-based program developed in the late 1990s and early 2000s to prevent relapse in people with recurrent major depression. It combines the structure and group format of Mindfulness-Based Stress Reduction (MBSR) with concepts and exercises drawn from cognitive therapy, integrated into a coherent program specifically designed to change a person's relationship to the depressive thinking that drives relapse.

MBCT is now recognized by several international guidelines, including the UK's National Institute for Health and Care Excellence (NICE), as an evidence-based option for the prevention of depressive relapse, particularly in people with three or more prior episodes. The program does not aim to suppress symptoms or fix problems; it teaches participants a different way of relating to thoughts, feelings, and bodily sensations — meeting them with awareness rather than reacting to them automatically. That shift in relationship is thought to protect against the cascades of rumination that can re-ignite depression.

1. Overview

MBCT is not a treatment for an acute depressive episode in the way that antidepressants, CBT, or interpersonal therapy are. It is designed for people who are currently well — in remission from depression — but who have a history of recurrent episodes and therefore face elevated risk of relapse. The program teaches participants to recognize early signs of returning depression and to respond to those signs in a different way than the automatic mental habits that have driven prior relapses.

The shift MBCT aims for is sometimes summarized as moving from a "doing mode" of mind — in which the mind reflexively tries to fix, analyze, solve, or escape every experience — to a "being mode" of mind in which experience can be observed, allowed, and met without immediate reaction. The doing mode is useful for practical problems but is poorly suited to the kind of inner experiences (sadness, fatigue, intrusive thoughts) that fuel depressive relapse. Trying to "solve" a sad mood often triggers the very rumination that pulls one downward.

The program is delivered in a group of typically 8 to 15 participants, meeting weekly for eight weeks. Sessions include guided meditation practices, brief teaching, dialogue about participants' experiences with practice, and exercises drawn from cognitive therapy. Daily home practice — roughly 45 minutes — is an essential part of the program and is the main mechanism through which the formal program produces lasting change.

2. Historical Origins

The Original Question

In the early 1990s, Zindel Segal, Mark Williams, and John Teasdale — clinical psychologists in Toronto, Bangor, and Cambridge respectively — were asked by the MacArthur Foundation to develop a maintenance form of cognitive therapy for the prevention of depressive relapse. Cognitive therapy was already known to be effective for acute depression and to produce some relapse-protective effects, but the existing protocols were not specifically designed for maintenance.

The Encounter with MBSR

As the team developed their understanding of relapse, they were drawn to the work of Jon Kabat-Zinn at the University of Massachusetts Medical Center. Kabat-Zinn had developed Mindfulness-Based Stress Reduction in 1979 for patients with chronic medical conditions and stress-related disorders. MBSR taught secularized mindfulness practices — drawn primarily from Buddhist traditions but framed in terms accessible to a Western medical population — in an eight-week group format.

Segal, Williams, and Teasdale recognized that mindfulness training might offer something cognitive therapy alone did not: a way of relating to depressive thoughts and feelings that did not depend on challenging or restructuring their content. If the problem in relapse is not the content of depressive thinking but the way the mind locks onto it, then a method that changes the relationship to thinking itself could be exactly what was needed.

Developing the Protocol

Through the 1990s, the team trained at the Center for Mindfulness in Massachusetts, then adapted the MBSR framework by adding specific elements from cognitive therapy. The result was published in 2002 as Mindfulness-Based Cognitive Therapy for Depression, with a second edition appearing in 2013.

The First Major Trials

An early randomized trial published by Teasdale and colleagues in 2000 in the Journal of Consulting and Clinical Psychology found that MBCT significantly reduced relapse rates in patients with three or more prior depressive episodes. Subsequent trials, including work led by Willem Kuyken and colleagues, broadly replicated the finding and extended it — including studies showing that MBCT could be a viable alternative to maintenance antidepressants for some patients.

The Mindfulness Field Today

MBCT now sits within a wider field of mindfulness-based interventions that includes MBSR, Mindfulness-Based Relapse Prevention for substance use, Mindfulness-Based Eating Awareness Training, and many others. MBCT remains the most thoroughly evidenced of these for a specific psychiatric application — the prevention of depressive relapse — and continues to be refined through ongoing research.

3. Theoretical Foundations

The Cognitive Model of Relapse

MBCT begins from a specific cognitive model of how depressive relapse occurs. In someone with a history of depression, even brief or mild sadness can activate patterns of thinking — rumination, self-criticism, hopelessness — that were learned during prior episodes. These patterns then escalate the low mood, recruit more negative thinking, and can pull the person into a full relapse. The episode is not necessary; the cognitive vulnerability is.

Doing Mode vs. Being Mode

A central distinction in MBCT is between two modes of mind. In doing mode, the mind operates by setting goals, monitoring discrepancies between current and desired states, and generating actions to close the gap. This is essential for practical tasks. Applied to inner experience — to a sad mood, an intrusive thought, a difficult emotion — doing mode produces rumination: a relentless attempt to fix what is wrong that paradoxically deepens what is wrong.

Being mode involves a different stance: experience is allowed and observed rather than analyzed and judged. The mind rests in direct contact with what is happening, without immediately needing to do anything about it. Being mode is not passive resignation; it is an alert, open attentiveness that creates space for skillful response rather than reactive habit.

Decentering

Decentering is the capacity to observe thoughts as mental events rather than as direct reports of reality. The thought "I am worthless" can be noticed as a thought arising in the mind rather than treated as a fact requiring action or argument. Decentering does not require believing the thought to be false; it requires recognizing that a thought is not, in itself, the same as reality.

Attention as a Trainable Capacity

MBCT treats attention as a skill that can be trained through deliberate practice. The body scan, sitting meditation, and other formal practices systematically develop the ability to notice where attention has gone, to return it gently and without judgment, and to direct it toward chosen objects (the breath, body sensations, sounds, thoughts).

Compassionate Awareness

The quality of attention cultivated in MBCT is specifically a kind, curious, and non-judgmental attention. Self-criticism, harshness, and the demand that experience be other than it is are recognized as obstacles to learning. Kindness toward one's own mind, especially the difficult parts of it, is treated as a central element of the practice.

4. How a Typical Course Works

Eligibility and Orientation

MBCT is typically offered to people who are currently in remission from depression but have a history of recurrent episodes (often three or more). A pre-course orientation interview with the teacher helps assess fit, set expectations, and identify any concerns about doing the program at this time.

The Eight Sessions

The program is delivered in eight weekly group sessions of about two to two-and-a-half hours each, plus a full-day silent practice session usually held between sessions six and seven. Each session has a specific theme and set of practices that build on what came before:

  • Session 1 — Awareness and Automatic Pilot: Introduction to mindfulness through the raisin exercise and the body scan; recognition that much of life is lived on automatic pilot
  • Session 2 — Living in Our Heads: Continued body scan practice; exploration of how thoughts about events differ from the events themselves
  • Session 3 — Gathering the Scattered Mind: Introduction to mindful movement and the three-minute breathing space; building attentional steadiness
  • Session 4 — Recognizing Aversion: Introduction to sitting meditation; noticing the mind's habit of pulling away from unpleasant experience
  • Session 5 — Allowing/Letting Be: Practicing turning toward difficulty in meditation; developing the capacity to allow experience as it is
  • Session 6 — Thoughts Are Not Facts: Deepening decentering through cognitive exercises and specific meditation instructions on thoughts
  • Day of Silent Practice: An extended period of guided practice between sessions, usually about 6 to 7 hours
  • Session 7 — How Can I Best Take Care of Myself?: Identifying early warning signs of relapse and constructing a relapse-prevention action plan
  • Session 8 — Maintaining and Extending New Learning: Consolidating gains and planning for continued practice after the program ends

Home Practice

Daily home practice of approximately 45 minutes is asked of participants throughout the program. This typically includes guided meditation recordings, short informal practices, and exercises related to that week's theme. The home practice is not optional; the program does not work as a series of weekly classes alone. The formal sessions support and orient practice, but practice between sessions is where most of the learning actually takes root.

After the Program

The eight-week program is a beginning, not an endpoint. Most teachers encourage some form of ongoing practice — at least informal practices throughout the day, with periodic return to formal sitting or body scan. Many MBCT programs offer follow-up sessions or alumni groups to support continued engagement.

5. Core Techniques

The Body Scan

The body scan is typically the first formal practice introduced. Lying down, participants direct attention systematically through the body — toes, feet, legs, torso, arms, neck, head — noticing whatever sensations are present without trying to change them. The body scan trains sustained attention, anchors awareness in physical experience, and begins to interrupt the habit of living entirely in the head.

Sitting Meditation

Sitting meditation is the central formal practice of the later weeks. Participants sit upright, alert and relaxed, and attend in succession to the breath, the body, sounds, and thoughts. Each anchor is held lightly; when the mind wanders, attention is returned without judgment to the chosen object. Over time, awareness becomes more spacious, holding multiple objects simultaneously rather than narrowly focused on one.

Mindful Movement

Drawn from yoga and other body-based practices, mindful movement involves slow, attentive physical movement — simple stretches, balances, and gentle yoga sequences — done with full awareness of bodily sensation. The aim is not exercise but attentive embodiment; movement provides another doorway into present-moment awareness.

The Three-Minute Breathing Space

A signature practice of MBCT, the three-minute breathing space is a brief, portable practice used many times a day. It has three steps: first, becoming aware of what is happening right now (thoughts, feelings, body); second, gathering attention to the breath; third, expanding awareness to include the body and the surrounding environment. The breathing space is used both as regular daily practice and as a deliberate response to difficult moments.

Recognizing Automatic Pilot

Through informal practices like mindful eating, mindful walking, and routine-activity awareness, participants learn to recognize when the mind has slipped into automatic pilot — going through actions without awareness — and to bring attention back to direct experience.

Identifying Thoughts as Thoughts

Specific exercises drawn from cognitive therapy help participants notice the gap between events and the thoughts about events. A typical exercise asks participants to imagine a scenario, notice the thoughts and feelings that arise, and compare their thoughts with what others in the group reported — making visible the fact that thoughts are constructions, not perceptions.

The Relapse Prevention Plan

In the final weeks of the program, participants identify their personal early warning signs of relapse — specific thoughts, feelings, bodily sensations, behaviors, and circumstances — and construct a written plan of skillful responses. The plan typically includes formal practices, informal practices, behavioral activities, social contacts, and when to seek professional help.

6. Conditions It Treats and Evidence Base

Prevention of Depressive Relapse

The most robust evidence for MBCT is in the prevention of depressive relapse in people with three or more prior episodes. Multiple randomized trials, including Teasdale and colleagues (2000), Ma and Teasdale (2004), and Kuyken and colleagues (2008, 2015), have shown significant reductions in relapse compared to usual care. A 2016 individual-participant data meta-analysis by Kuyken and colleagues, including more than 1,250 patients across nine randomized trials, found that people who received MBCT had a lower risk of relapse over 60 weeks than those who did not (a hazard ratio of about 0.69), and a somewhat lower risk even compared with active treatments such as maintenance antidepressants. Benefits appeared larger for people with more severe residual symptoms.

Acute Depression

Evidence for MBCT in acute, current depression is more limited and less consistent than in maintenance. The program was not originally designed for acute episodes, and the sustained attention practices it requires can be difficult when concentration is impaired. Some adaptations have been developed for current depression, but acute episodes are usually better addressed first with established acute treatments such as CBT, IPT, behavioral activation or medication, with MBCT considered for relapse prevention once remission is achieved.

Anxiety Disorders

A growing body of research supports MBCT for generalized anxiety disorder, social anxiety, and mixed anxiety presentations. Effect sizes are generally moderate; MBCT is one of several mindfulness-based options in this domain rather than a clear first-line treatment.

Bipolar Disorder

MBCT has been studied as an adjunct to standard treatment for bipolar disorder, with some evidence for benefits on anxiety, depressive symptoms between episodes, and emotion regulation. It is not a stand-alone treatment for bipolar disorder.

Chronic Pain and Medical Illness

Adaptations of MBCT have been studied in chronic pain, cancer (notably MBCT for Cancer, developed by Trish Bartley), and other chronic medical conditions, with broadly positive effects on psychological adjustment, distress, and quality of life.

Eating Concerns

Mindfulness-based approaches more broadly have shown promise in binge eating, emotional eating, and weight-management contexts. MBCT-specific protocols for eating concerns are less standardized than the parent program but represent an active area of development.

Suicidality

Research led by Mark Williams and colleagues has examined MBCT in patients with histories of suicidal depression, with findings suggesting possible benefits for some participants, particularly those with histories of childhood adversity. This work is preliminary, and anyone experiencing suicidal thoughts should seek immediate help; see crisis resources.

Guideline Recognition

NICE in the United Kingdom recommends MBCT as an option for the prevention of depressive relapse in people with three or more prior episodes. Other clinical guidelines, including those of the Canadian Network for Mood and Anxiety Treatments (CANMAT), similarly include MBCT among evidence-based options for relapse prevention.

7. Comparison with Other Therapies

MBCT vs. MBSR

MBCT and Mindfulness-Based Stress Reduction share an eight-week, group-based structure and a substantial overlap of practices — body scan, sitting meditation, mindful movement, a day of silence. They differ in focus and added content. MBSR is a general program for stress, chronic illness, and life difficulty; MBCT integrates specific cognitive-therapy content and is targeted at preventing depressive relapse. The cognitive elements of MBCT — exercises around the thoughts-versus-facts distinction, identifying warning signs, building a relapse-prevention plan — are not part of MBSR.

MBCT vs. Traditional CBT

Cognitive-behavioral therapy aims to identify and change distorted or unhelpful thoughts and behaviors. MBCT aims to change the relationship to thoughts rather than the thoughts themselves. In CBT, a depressive thought may be examined for evidence, evaluated for accuracy, and replaced with a more balanced one. In MBCT, the same thought is recognized as a thought, observed without engagement, and allowed to pass without becoming the launching point for rumination.

Both can be effective; they work in different ways and may suit different people. Many practitioners draw on both approaches in integrated treatment.

MBCT vs. Maintenance Antidepressants

For patients in remission from recurrent depression, maintenance antidepressants and MBCT are both supported by evidence as relapse-prevention strategies. The Kuyken (2015) PREVENT trial directly compared MBCT (with optional discontinuation of antidepressants) with maintenance antidepressants in patients with recurrent depression and found broadly comparable relapse rates. This research suggests MBCT can be an option to discuss for people who would prefer not to remain on long-term medication, but medication changes should only be made in consultation with the prescribing doctor.

MBCT vs. ACT and DBT

Acceptance and Commitment Therapy and Dialectical Behavior Therapy also incorporate mindfulness as a core component, but in different frameworks. ACT pairs mindfulness with values-based action; DBT uses mindfulness as one of four skill modules within a broader treatment for emotion dysregulation. MBCT is more specifically focused on depressive relapse prevention and follows a more standardized eight-week format.

8. Who Provides It and How to Find a Therapist

Teacher Training

MBCT teachers typically have a clinical background — clinical psychology, psychiatry, nursing, social work, or counseling — and substantial training in mindfulness teaching. Recognized teacher training pathways include the Oxford Mindfulness Centre, the Centre for Mindfulness Studies in Toronto, the UC San Diego Mindfulness-Based Professional Training Institute, the University of California San Francisco, Bangor University, and other accredited programs.

Personal Practice Requirement

A defining feature of MBCT teacher training is the requirement that teachers have a substantial personal mindfulness practice — typically including attendance at multi-day silent retreats. The expectation is that teachers cannot effectively guide others through a process they have not themselves undertaken. This requirement distinguishes MBCT teaching from many other psychotherapy trainings.

Where MBCT Is Offered

MBCT is offered through academic medical centers, mindfulness centers, mental health clinics, and some private practices. In the United Kingdom, NHS Talking Therapies (formerly IAPT) services offer MBCT in many regions. Programs are increasingly available online, though most teachers and researchers prefer in-person delivery when feasible, given the role of group dynamics in the program.

Questions to Ask

  • What is your training pathway, and from which program did you complete your teacher training?
  • How long have you maintained a personal mindfulness practice?
  • Do you teach the standard MBCT curriculum, or a modified version?
  • How do you handle participants who find the practices difficult or who experience emerging emotional material?
  • Is the program in person or online, and what are the group size and structure?

Practical Considerations

MBCT is a significant time commitment — about 30 hours of class plus around 35 hours of home practice over eight weeks. Costs vary by setting; some programs are covered by insurance, others are not, and some are offered free in NHS or academic settings. The find a therapist page can help orient your search, and the Oxford Mindfulness Centre and Center for Mindfulness Studies maintain teacher directories.

9. Limitations and Criticisms

Not for Acute Episodes

MBCT is designed for relapse prevention, not for acute depression. The sustained attention and home practice the program requires are difficult when concentration is severely impaired, motivation is depleted, or hopelessness is dominant. People in acute episodes are usually better served by other evidence-based acute treatments first, with MBCT considered later for maintenance.

Group Format Constraints

The standard MBCT format is a group of typically 8 to 15 people. For some patients — those with severe social anxiety, certain trauma histories, or strong preferences for individual work — the group format itself can be a barrier. Adaptations for individual delivery exist but are less standardized and less well-evidenced.

Time Commitment

The 45-minute daily home practice is substantial. Some studies link more home practice to better outcomes, although it is not clear exactly how much is needed, and the demand is real and limits accessibility for people with caregiving responsibilities, demanding work, or chronic fatigue.

Mindfulness Is Not Universally Beneficial

Recent research has documented that mindfulness practice can produce difficult experiences for some practitioners — increased anxiety, emerging traumatic memories, dissociation, and in rare cases, episodes of significant distress. A well-trained MBCT teacher will screen for vulnerability, discuss these possibilities openly, and know how to respond when difficulty arises. Programs run by less experienced teachers, or marketed as universally beneficial, can underestimate the risks.

Risk of Spiritual or Conceptual Decoupling

MBCT presents mindfulness in secular, clinical terms. This makes the practices accessible to a wide range of participants but has also drawn criticism from teachers within contemplative traditions who argue that important ethical and philosophical context is lost. Whether this matters clinically is debated, but it is part of an ongoing conversation in the field.

Limited Evidence in Some Populations

While the evidence for MBCT in recurrent depression is strong, the evidence in other populations — children and adolescents, people with severe mental illness, populations underrepresented in trials — is more limited. Generalizing across populations should be done with appropriate caution.

10. What to Expect in Your First Sessions

The Pre-Course Interview

Most MBCT programs begin with an individual orientation meeting with the teacher. This interview gathers basic clinical history, assesses fit, explains what the program asks of participants, and gives both you and the teacher a chance to decide whether this is the right program at the right time.

The First Session

The first session typically begins with introductions, an overview of the program, and the raisin exercise — a deliberately slow, attentive eating of a single raisin that introduces the basic stance of mindful attention. The body scan is introduced, often with the first guided practice happening in the room. Home practice for the week — daily body scan with a guided recording — is assigned.

The Early Weeks

The first three or four weeks tend to feel unfamiliar. Many participants discover that their minds wander far more than they had realized, that sitting still with attention is harder than expected, and that practices like the body scan can produce drowsiness, restlessness, or unexpected emotion. The teacher will normalize these experiences — they are not signs of doing it wrong; they are exactly what the practices are designed to reveal.

What to Bring

  • A willingness to commit to daily home practice for the duration of the program
  • Curiosity rather than expectation about what will happen
  • Openness to a group setting, including hearing others' experiences and sharing your own to the extent you are comfortable
  • Patience with the unfamiliar nature of the practices

Common Early Experiences

People often notice in the first weeks that practice is uneven — some days easy, some days frustrating. The mind wanders constantly. Sleepiness during the body scan is extremely common. None of this is failure; the noticing itself is the practice. As the weeks go on, most participants find their relationship to attention, thought, and feeling beginning to shift, often in subtle ways that become clearer in retrospect.

The Day of Silent Practice

Between sessions six and seven, the program typically includes a full-day silent practice session, usually 6 to 7 hours of guided and unguided meditation, mindful movement, and mindful eating, in silence. This day often produces a deeper level of practice than the weekly sessions alone and is a memorable part of the program for most participants.

After the Program

The end of the eight weeks is the beginning, not the conclusion. Continued informal and formal practice is what carries the benefits forward. Many participants find that practice naturally reshapes how they handle stress, mood, and difficult thoughts, even when formal sitting becomes less consistent than during the program itself.

Conclusion

Mindfulness-Based Cognitive Therapy occupies a specific and well-evidenced place in the landscape of psychological treatments. It is not for everyone, and it is not for every stage of every condition. For people with recurrent depression who are currently well and at risk of relapse, MBCT offers a structured, evidence-based way to build the attentional and metacognitive skills that protect against the cognitive cascades driving relapse.

What MBCT teaches goes beyond relapse prevention in any narrow sense. Participants typically describe lasting changes in how they relate to their own thoughts, feelings, and bodily experience — meeting difficulty with more space and less reactivity, recognizing automatic pilot when it arises, and making more deliberate choices about where attention goes. These shifts have value beyond the program's original indication.

For people considering MBCT, useful next steps are checking with a clinician that the timing is right (usually not during an acute episode), finding a well-trained teacher, and planning realistically for the eight weeks of classes and home practice. Our guides to mindfulness-based therapies and finding a therapist may help. The program asks a lot, and for many people who complete it, research suggests it offers a more workable relationship with their own minds and a lower risk of depression returning.

Frequently asked questions

What is the difference between MBCT and MBSR?

Both are eight-week group programs built on the same mindfulness practices. MBSR, developed by Jon Kabat-Zinn in 1979, is a general program for stress, pain and illness. MBCT adapts MBSR specifically for people with recurrent depression, adding cognitive therapy elements such as learning about depression, recognizing that thoughts are not facts, and creating a personal relapse-prevention plan.

Who is MBCT for?

MBCT was designed for adults who have recovered from repeated episodes of depression and want to reduce the chance of it returning. Research benefits are clearest for people with three or more past episodes. It is generally not recommended as the main treatment during a severe, current episode, when concentration and motivation are often too impaired for the practices.

Can MBCT replace antidepressant medication?

Some trials, notably the PREVENT trial in 2015, found that MBCT combined with support to gradually reduce medication produced relapse rates similar to staying on maintenance medication. This does not mean anyone should stop medication on their own. Any change to medication should be planned with the prescribing doctor, since stopping suddenly can cause problems and increase relapse risk.

How much home practice does MBCT involve?

Participants are usually asked to practice for about 30 to 45 minutes a day, six days a week, using guided recordings and short informal exercises. This is a significant commitment. Some studies link more practice to better outcomes, though it is not clear exactly how much is needed, and teachers generally encourage people to do what they realistically can.

Can mindfulness have negative effects?

For most people mindfulness practice is safe, but a minority report difficult experiences such as increased anxiety, distressing memories or feeling detached. Trained MBCT teachers screen participants, explain these possibilities, and adapt practices when needed. People with recent trauma, active psychosis or severe depression should discuss suitability with a professional before joining a program.

Sources

  1. Segal, Z. V., Williams, J. M. G., & Teasdale, J. D. (2013). Mindfulness-Based Cognitive Therapy for Depression (2nd ed.). Guilford Press.
  2. Teasdale, J. D., Segal, Z. V., Williams, J. M. G., Ridgeway, V. A., Soulsby, J. M., & Lau, M. A. (2000). Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Journal of Consulting and Clinical Psychology, 68(4), 615–623.
  3. Ma, S. H., & Teasdale, J. D. (2004). Mindfulness-based cognitive therapy for depression: Replication and exploration of differential relapse prevention effects. Journal of Consulting and Clinical Psychology, 72(1), 31–40.
  4. Kuyken, W., Hayes, R., Barrett, B., et al. (2015). Effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of depressive relapse or recurrence (PREVENT): A randomised controlled trial. The Lancet, 386(9988), 63–73.
  5. Kuyken, W., Warren, F. C., Taylor, R. S., et al. (2016). Efficacy of mindfulness-based cognitive therapy in prevention of depressive relapse: An individual patient data meta-analysis from randomized trials. JAMA Psychiatry, 73(6), 565–574.
  6. National Institute for Health and Care Excellence. (2022). Depression in adults: treatment and management (NICE guideline NG222).

About this page. Written and reviewed by the iPsychology Editorial Team using peer-reviewed research, textbooks and guidance from bodies such as the APA, NIMH, NHS and WHO. Content is educational and is not a substitute for professional advice. Spotted an error? Let us know.